In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

• Apoptosis
• Biomedicine
• Cell
• Hetz
• Protein
• Regulator
• cell  Dynamics
• physiology  protein
• family  regulation

• Front Matter
• Homeostatic Functions of BCL-2 Proteins beyond Apoptosis
• Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum
• Diego Rojas-Rivera, Benjamin Caballero, Sebastian Zamorano,
• BH3-Only Proteins and Their Effects on Cancer
• Endoplasmic Reticulum Stress and BCL-2 Family Members
• Targeting Survival Pathways in Lymphoma
• The Interplay between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis
• Noncanonical Functions of BCL-2 Proteins in the Nervous System
• Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis
• Back Matter

Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile

Claudio Hetz

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA

Claudio Hetz

Book Title：BCL‑2 Protein Family

Book Subtitle：Essential Regulators of Cell Death

Authors：Claudio Hetz

DOI：https://doi.org/10.1007/978-1-4419-6706-0

eBook Packages：Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

Edition Number：1

Number of Pages：XVII, 145

Number of Illustrations：/

Topics:Human Physiology, Protein Science, Biomedicine general, Molecular Medicine